Ethyl Ferulate, a Component with Anti-Inflammatory
Ethyl Ferulate (FAEE), which has many health benefits, is widely used in creams to provide high sun protection. We compared FAEE to its precursor, Ferulic acid (FA) as free radical scavengers, inhibitors oxidants from leukocytes and the changes in the rheological property when FAEE is incorporated into emulsion-based creams. FA had a lower cell-free antiradical ability than FA. FAEE was however more effective in reducing reactive oxygen species from activated leukocytes. The formulations were more elastic than viscous in frequency sweep and stress tests. The creep and recovery assay confirmed the viscoelastic characteristics of the formulations and revealed that FAEE was less susceptible to deformation. Liberation experiments revealed that FAEE was released at a slower rate than FA. FAEE is less effective than FA in preventing oxidative damage caused by oxidants produced by leukocytes. The rheological changes caused by FAEE's addition are indicative of lower readability. This coul...